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KMID : 1039520200240020053
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Journal of Audiology & Otology
2020 Volume.24 No. 2 p.53 ~ p.60
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Experimental Animal Models for Meniere’s Disease: A Mini-Review
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Seo Young-Joon
Brown Daniel
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Abstract
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Several novel animal models that represent the pathophysiological process of endolymphatic hydrops (ELH) of Meniere’s disease (MD) have been developed. Animal models are important to identify and characterize the pathophysiology of ELH and to corroborate molecular and genetic findings in humans. This review of the current animal models will be useful in understanding the pathophysiology of and developing proper treatments for MD. Surgical animal models will be replaced by medication-induced animal models. Study models previously developed in guinea pigs will be developed in several smaller animals for ease of conducting molecular analysis. In this review, we provided updated resources including our previous studies regarding the current and desirable animal models for MD.
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KEYWORD
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Endolymphatic hydrops, Meniere’s disease, Animal model, Endolymphatic sac, Lipopolysaccharide
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